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Groundbreaking Study Demonstrates 20-Year Remission in Pemphigus Vulgaris Patients Using IVIg Therapy

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Research published in the prestigious Proceedings of the National Academy of Sciences of the United States of America (PNAS) offers hope for long-term remission in patients with pemphigus vulgaris (PV), a potentially fatal autoimmune blistering disease. Researchers from Tufts University School of Medicine (Boston, MA) and Sorbonne Université (Paris, France) have demonstrated a remarkable 20-year clinical and serological remission in patients using a defined protocol of intravenous immunoglobulin (IVIg) therapy.

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Restoring immune tolerance in pemphigus vulgaris

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Intravenous immunoglobulin (IVIg), a preparation of polyclonal serum IgG pooled from numerous blood donors, has been used for nearly three decades and is proving to be an efficient treatment for many autoimmune blistering diseases, including pemphigus vulgaris (PV). Despite its widespread use and therapeutic success, its mechanisms of action are not completely understood. Some of its anti-inflammatory and immunomodulatory actions have been studied. In this study, the authors present a twenty-year follow-up of 21 patients with clinical and immunopathological confirmed PV, treated with IVIg as monotherapy, according to an established published protocol.

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Pemphigoid of the Pulmonary System (POPS): A Review of a Less Recognized Feature

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Pemphigoid (Pg) diseases are a group of potentially fatal autoimmune mucocutaneous diseases. They have different clinical phenotypes, involving only the skin or multiple mucous membranes. They occur globally and frequently affect the elderly. The common marker among all variants is the presence of autoantibodies targeting the dermal-epidermal or mucosal-submucosal junctions, or basement membrane zone (BMZ). Four target antigens in the BMZ were studied.

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Molecular Basis for Global Incidence of Pemphigoid Diseases and Differences in Phenotypes

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Pemphigoid (Pg) diseases are a group of potentially fatal autoimmune mucocutaneous diseases. They have different clinical phenotypes, involving only the skin or multiple mucous membranes. They occur globally and frequently affect the elderly. The common marker among all variants is the presence of autoantibodies targeting the dermal-epidermal or mucosal-submucosal junctions, or basement membrane zone (BMZ). Four target antigens in the BMZ were studied.

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 Use of Rituximab in the Treatment of Mucous Membrane Pemphigoid: An Analytic Review 

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Pemphigoid (Pg) diseases are a group of potentially fatal autoimmune mucocutaneous diseases. They have different clinical phenotypes, involving only the skin or multiple mucous membranes. They occur globally and frequently affect the elderly. The common marker among all variants is the presence of autoantibodies targeting the dermal-epidermal or mucosal-submucosal junctions, or basement membrane zone (BMZ). Four target antigens in the BMZ were studied.

 Use of Rituximab in the Treatment of Mucous Membrane Pemphigoid: An Analytic Review  Read More »

Molecular Basis for Global Incidence of Pemphigoid Diseases and Differences in Phenotypes

Molecular Basis for Global Incidence of Pemphigoid Diseases and Differences in Phenotypes

Uncategorized /

Pemphigoid (Pg) diseases are a group of potentially fatal autoimmune mucocutaneous diseases. They have different clinical phenotypes, involving only the skin or multiple mucous membranes. They occur globally and frequently affect the elderly. The common marker among all variants is the presence of autoantibodies targeting the dermal-epidermal or mucosal-submucosal junctions, or basement membrane zone (BMZ). Four target antigens in the BMZ were studied.

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IgM Deficiency in Autoimmune Blistering Mucocutaneous Diseases Following Various Treatments: Long Term Follow-Up and Relevant Observations

IgM Deficiency in Autoimmune Blistering Mucocutaneous Diseases Following Various Treatments: Long Term Follow-Up and Relevant Observations

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Link to original article: https://www.frontiersin.org/articles/10.3389/fimmu.2021.727520/full A. Razzaque Ahmed1,2* and Merve Aksoy1 1Department of Dermatology, The Center for Blistering Diseases, Tufts University School of Medicine, Boston, MA, United States 2Dermatology Service, Boston Veterans Administration Health Services, Boston, MA, United States IgM deficiency has been reported in patients with many autoimmune diseases treated with Rituximab (RTX). It has not

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What are autoimmune diseases?

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One of the functions of the immune system is to protect the body by responding to invading microorganisms, such as viruses or bacteria, by producing antibodies or sensitized lymphocytes (types of white blood cells). Under normal conditions, an immune response cannot be triggered against the cells of one’s own body. In some cases, however, immune cells make a mistake and attack the very cells that they are meant to protect……

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