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Molecular Basis for Global Incidence of Pemphigoid Diseases and Differences in Phenotypes

Molecular Basis for Global Incidence of Pemphigoid Diseases and Differences in Phenotypes

Pemphigoid (Pg) diseases are a group of potentially fatal autoimmune mucocutaneous diseases. They have different clinical phenotypes, involving only the skin or multiple mucous membranes. They occur globally and frequently affect the elderly. The common marker among all variants is the presence of autoantibodies targeting the dermal-epidermal or mucosal-submucosal junctions, or basement membrane zone (BMZ). Four target antigens in the BMZ were studied.

IgM Deficiency in Autoimmune Blistering Mucocutaneous Diseases Following Various Treatments: Long Term Follow-Up and Relevant Observations

IgM Deficiency in Autoimmune Blistering Mucocutaneous Diseases Following Various Treatments: Long Term Follow-Up and Relevant Observations

Link to original article: https://www.frontiersin.org/articles/10.3389/fimmu.2021.727520/full A. Razzaque Ahmed1,2* and Merve Aksoy1 1Department of Dermatology, The Center for Blistering Diseases, Tufts University School of Medicine, Boston, MA, United States 2Dermatology Service, Boston Veterans Administration Health Services, Boston, MA, United States IgM deficiency has been reported in patients with many autoimmune diseases treated with Rituximab (RTX). It has not …

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