Pemphigus Vulgaris (PV) Treatment Strategies


Pemphigus vulgaris (PV) is an autoimmune mucocutaneous blistering disease (AMBD). AMBDs are a group of frequently fatal diseases, clinically characterized by erosions and/or blisters on the skin and mucous membranes (Van Beek 2018). PV is a chronic disease which usually takes years to evolve (Almugairen 2013). Death usually occurs due to septicemia with Streptococcus aureus, and the skin is usually the source of infection (Ahmed 1982). These dermatoses are histologically characterized by autoantibodies directed against structural proteins in the cadherins, called desmogleins (e.g., desmoglein-1, desmoglein-3), which the autoantibodies conceive as antigens, in the skin and mucous membranes… Read more here.