IVIG

Groundbreaking Study Demonstrates 20-Year Remission in Pemphigus Vulgaris Patients Using IVIg Therapy

January 29, 2024

Research published in the prestigious Proceedings of the National Academy of Sciences of the United States of America (PNAS) offers hope for long-term remission in patients with pemphigus vulgaris (PV), a potentially fatal autoimmune blistering disease. Researchers from Tufts University School of Medicine (Boston, MA) and Sorbonne Université (Paris, France) have demonstrated a remarkable 20-year clinical and serological remission in patients using a defined protocol of intravenous immunoglobulin (IVIg) therapy.

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Restoring immune tolerance in pemphigus vulgaris

January 24, 2024

Intravenous immunoglobulin (IVIg), a preparation of polyclonal serum IgG pooled from numerous blood donors, has been used for nearly three decades and is proving to be an efficient treatment for many autoimmune blistering diseases, including pemphigus vulgaris (PV). Despite its widespread use and therapeutic success, its mechanisms of action are not completely understood. Some of its anti-inflammatory and immunomodulatory actions have been studied. In this study, the authors present a twenty-year follow-up of 21 patients with clinical and immunopathological confirmed PV, treated with IVIg as monotherapy, according to an established published protocol.

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Pemphigoid of the Pulmonary System (POPS): A Review of a Less Recognized Feature

December 21, 2022

Pemphigoid (Pg) diseases are a group of potentially fatal autoimmune mucocutaneous diseases. They have different clinical phenotypes, involving only the skin or multiple mucous membranes. They occur globally and frequently affect the elderly. The common marker among all variants is the presence of autoantibodies targeting the dermal-epidermal or mucosal-submucosal junctions, or basement membrane zone (BMZ). Four target antigens in the BMZ were studied.

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Molecular Basis for Global Incidence of Pemphigoid Diseases and Differences in Phenotypes

December 21, 2022

Pemphigoid (Pg) diseases are a group of potentially fatal autoimmune mucocutaneous diseases. They have different clinical phenotypes, involving only the skin or multiple mucous membranes. They occur globally and frequently affect the elderly. The common marker among all variants is the presence of autoantibodies targeting the dermal-epidermal or mucosal-submucosal junctions, or basement membrane zone (BMZ). Four target antigens in the BMZ were studied.

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 Use of Rituximab in the Treatment of Mucous Membrane Pemphigoid: An Analytic Review 

December 21, 2022

Pemphigoid (Pg) diseases are a group of potentially fatal autoimmune mucocutaneous diseases. They have different clinical phenotypes, involving only the skin or multiple mucous membranes. They occur globally and frequently affect the elderly. The common marker among all variants is the presence of autoantibodies targeting the dermal-epidermal or mucosal-submucosal junctions, or basement membrane zone (BMZ). Four target antigens in the BMZ were studied.

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Molecular Basis for Global Incidence of Pemphigoid Diseases and Differences in Phenotypes

Molecular Basis for Global Incidence of Pemphigoid Diseases and Differences in Phenotypes

February 2, 2022

Pemphigoid (Pg) diseases are a group of potentially fatal autoimmune mucocutaneous diseases. They have different clinical phenotypes, involving only the skin or multiple mucous membranes. They occur globally and frequently affect the elderly. The common marker among all variants is the presence of autoantibodies targeting the dermal-epidermal or mucosal-submucosal junctions, or basement membrane zone (BMZ). Four target antigens in the BMZ were studied.

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Nerves

What are autoimmune diseases?

January 21, 2019

One of the functions of the immune system is to protect the body by responding to invading microorganisms, such as viruses or bacteria, by producing antibodies or sensitized lymphocytes (types of white blood cells). Under normal conditions, an immune response cannot be triggered against the cells of one’s own body. In some cases, however, immune cells make a mistake and attack the very cells that they are meant to protect……

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IVIG

What is IVIG?

January 21, 2019

IVIG stands for intravenous immunoglobulin. It is a purified plasma treatment that contains antibodies collected from the plasma of healthy donors and purified through a special process so that the therapy is safe and effective. Most of the antibodies are of the IgG class of antibodies, also called immunoglobulin G…..

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Dr. Sohail Masood

Meet Dr. Masood

January 21, 2019

Dr. Sohail Masood is a well-known pioneer and serial entrepreneur in the home infusion industry. Dr. Masood started one of the first home infusion pharmacies in California in 1990 after graduating from USC School of Pharmacy. Over the years, his passion and drive…..

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